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Liberpro Advantage Market Milestones
Technology Advantage Market

 

Milestones for pGRF Plasmid DNA


Date Milestone
Mar 1999 Showed efficacy and safety in mice
Jul 1999 Showed efficacy and safety on pigs
Jul 2001 Permit issued by the Ministry of Agriculture (MOA) for Intermediate Trial in Guangdong and Sichuan Provinces (large scale trials)
Jul 2002 MOA permit for Environmental Release Phase of Field Testing.
Nov 2002 Patent US6486134 granted by the USPTO (photocopy)
Jul 2003 Successfully completed the Production Scale Field Testing Phase
Dec 2003 Granted Safety Permits from the MOA’s Committee on the Safety of Recombinant Organisms
Jun 2006 European Patent EP 1218508 granted   (photocopy)
Oct 2008 Patent granted by the State Intellectual Property Office of China   (photocopy)
2009 (expected) Successful registration of pGRF Plasmid DNA with MOA of China
2009 (expected) Successful registration of pGRF Plasmid DNA with BFAD of Philippines

 

Future Direction


Second generation plasmids with enhanced gene expression

Advanced formulations to increase cellular uptake of plasmid, thus lowering dosage

Develop broad-acting immunomodulating DNA biologics for veterinary use, including:

  • Interferon α
  • Interleukins
  • Thymosin

 

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